synthesis of highly stereodefined tetrasubstituted acyclic all

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(,-xylyl)phosphate formation of stereoenriched tertiary alcohols, followed by in situ syn-elimination of the corresponding phosphates under mild : Ngiap-Kie Lim, Patrick Weiss, Beryl X. Li, Christina H. McCulley, Stephanie R. Hare, Bronwyn L. Bens

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(,-xylyl)phosphate formation of stereoenriched tertiary : Ngiap-Kie Lim, Patrick Weiss, Beryl X. Li, Christina H. McCulley, Stephanie R. Hare, Bronwyn L. Bens

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis&#;(,-xylyl)&#;phosphate formation of st

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; Europe PMC is an archive of life sciences journal literature. An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed : Ngiap-Kie Lim, Patrick Weiss, Beryl X. Li, Christina H. McCulley, Stephanie R. Hare, Bronwyn L. Bens

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(,-xylyl)phosphate formation of stereoenriched tertiary alcohols,

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; Europe PMC is an archive of life sciences journal literature. An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; Download Citation | Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn -Elimination Approach | An efficient synthesis of

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis&#;(,-xylyl)&#;phosphate formation of stereoenriched tertiary

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic Hence, the preparation of stereodefined tetrasubstituted acyclic all-carbon olefins remains a stimulating challenge for the synthetic organic community. During our process

Highly selective synthesis of all-carbon tetrasubstituted-- &#; The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis&#;(,-xylyl)&#;phosphate formation of st

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis&#;(,-xylyl)&#;phosphate formation of stereoenriched tertiary alcohols, followed by in situ syn-elimination of the corresponding phosphates under mild conditions. This chemistry tolerates a wide variety of electronically and sterically diverse

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic Hence, the preparation of stereodefined tetrasubstituted acyclic all-carbon olefins remains a stimulating challenge for the synthetic organic community. During our process development of GDC-, a selective estrogen receptor degrader in clinical studies for the treatment of metastatic breast cancer,c we sought to advance an efficient

Genentech: Haiming Zhang | Director & Distinguished -- &#; Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach Organic Letters, ISSN:

Construction of tetrasubstituted stereocenters via -- &#; We first examined our newly developed chiral acyclic secondary amine catalysts in the previously unrealized acetaldehyde Mannich reaction with β,γ-alkynyl-α-imino esters. β,γ-Alkynyl-α-imino esters, as an important class of highly stable and easy accessible ketimines, have been recognized as useful precursors for the synthesis of alkynyl

Stereoselective Synthesis of Tetrasubstituted Olefins -- &#; Migrating through Si valley: The highly stereoselective formation of α-silyl-β- haloenones by way of silicon group migration is described.Electrophilic activation of the alkyne by N-halosuccinimides induced an anti-selective migration to give highly substituted enones (see scheme).These enone products can be readily converted to the all-carbon

Bis(,-dimethylphenyl) Chlorophosphate -- | Dehydration Agent for the Synthesis of Tetra-substituted Olefins References Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach

Azo group-enabled metal- and oxidant-free alkenyl C–H Metal- and oxidant-free alkenyl C–H thiolation enabled by the azo group had been established for the modular synthesis of tetrasubstituted acyclic olefins. The reaction was performed under mild reaction conditions with a broad substrate scope.

Highly Diastereo- and Enantioselective Aldol Reactions of -- &#; The enantioselective synthesis of acyclic all-carbon quaternary centers remains a significant challenge in organic synthesis. [] In view of the tremendous utility of enantioselective aldol reactions in organic synthesis, extension of this reaction to the enantioselective synthesis of all-carbon quaternary centers from stereochemically

Dynamic Kinetic Resolution of Alkenyl Cyanohydrins-- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(,-xylyl)phosphate formation of stereoenriched tertiary alcohols, followed by in

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(,-xylyl)phosphate formation of stereoenriched tertiary alcohols, followed by in situ syn-elimination of the corresponding phosphates under mild conditions.

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic -- &#; An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis&#;(,-xylyl)&#;phosphate formation of stereoenriched tertiary alcohols, followed by in situ syn-elimination of the corresponding phosphates under mild conditions. This chemistry tolerates a wide variety of electronically and sterically diverse

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic Hence, the preparation of stereodefined tetrasubstituted acyclic all-carbon olefins remains a stimulating challenge for the synthetic organic community. During our process development of GDC-, a selective estrogen receptor degrader in clinical studies for the treatment of metastatic breast cancer,c we sought to advance an efficient

Palladium-Catalyzed One-Step Synthesis of Stereodefined -- &#; Introduction. Tetrasubstituted olefins have attracted tremendous attention because their fundamental structural motifs are found in numerous biologically active compounds. , To date, many transition-metal-catalytic processes for constructing tetrasubstituted olefins have been reported. – Of all the excellent work in this area,

pubs.rsc.orgSynthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach Ngiap-Kie Lim, Patrick Weiss, Beryl X. Li, Christina H. McCulley, Stephanie R. Hare, Bronwyn L. Bensema, Teresa A. Palazzo, Dean J. Tantillo, Haiming Zhang and Francis Gosselin

Olefin functionalization/isomerization enables -- &#; Developing protocols that afford stereochemically defined acyclic tri- and tetrasubstituted alkenes is a longstanding goal in organic synthesis. These highly substituted C=C bonds (-aryl(boryl)-

Palladium-Catalyzed One-Step Synthesis of Stereodefined -- &#; Efficiently modifying glycals by directly introducing functional groups into their double bonds is a long-standing challenge. Here, the strategy of introducing two different functional groups into -iodoglycals to obtain modified glycals in one step through palladium catalysis was reported for the first time, and the modified glycals contained stereodefined

Construction of tetrasubstituted stereocenters via -- &#; We first examined our newly developed chiral acyclic secondary amine catalysts in the previously unrealized acetaldehyde Mannich reaction with β,γ-alkynyl-α-imino esters. β,γ-Alkynyl-α-imino esters, as an important class of highly stable and easy accessible ketimines, have been recognized as useful precursors for the synthesis of alkynyl

Azo group-enabled metal- and oxidant-free alkenyl C–H Metal- and oxidant-free alkenyl C–H thiolation enabled by the azo group had been established for the modular synthesis of tetrasubstituted acyclic olefins. The reaction was performed under mild reaction conditions with a broad substrate scope.

Dean J. Tantillo - PublicationsSynthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach. Organic Letters. PMID DOI: ./Acs.Orglett.B : .: : Zhu JS, Son JH, Teuthorn AP, Haddadin MJ, Kurth MJ, Tantillo DJ. Correction to "Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected